A few weeks ago I rooted my phone to get access to some features made inaccessable by Verizon. This was taken a step further this week when I installed a custom ROM on to replace the stock ROM on my HTC Incredible. I had had enough of the stock ROM when I realized after rooting it that I still couldn't get rid of Skype or Peep easily.
I had to do something and remembered the cool thing about Android being open source software is any can modify it and come up with a custom flavor. This is also the problem. Google research took me on a long search through Android related message boards where the consensus seemed to be a flavor called Skyraider. This flavor also has a variant that includes HTC Sense UI which I prefer over the vanilla Android UI. I downloaded it via ROM Manager which I purchased for $3.99 from the Android Marketplace.
After downloading Skyraider I tried to install it via ROM Manager. What I found out next is the radio software needed to be updated. After that I was good to go and all my crapware was gone. As it turns out it used my old system settings and desktop. In case it forgot I took the precaution by backing everything up with Titanium Backup.
Proceed at your own risk for things can go wrong and brick your phone.
More detailed information and step-by-step instructions from the XDA developers forum.